Bipolar affective disorder (manic-depression) is an illness with periods of unnaturally high mood and other periods of unnaturally low mood (episodes of mania and episodes of depression). Mania is a state of excessively elevated mood and excessive activity, sometimes accompanied with unjustified ideas of self-importance (grandiose delusions). Depression is an episode of very low mood with an overwhelming sense of hopelessness and worthlessness. Manic-depression affects men as much as women.
Global Burden of Disease estimated in 2002 Manic-depression caused 2.5% of all years spent living with a disability worldwide, 2.5% of all male and 2.4% of all female disability.
Deaths due to Suicide Map 482, some of which will be due to manic-depression, are counted separately. There is also an increased risk of Accidental death Map 474, because in a state of mania, ability to assess risk is impaired. Therefore the true mortality from bipolar affective disorder is not shown in the figures here.
Excluding deaths from suicide and accident, Manic-depression caused 0.0013% of all deaths worldwide in 2002, an average of 1 death per 10 million people per year, compared to an average of 140 suicides per million people.